Virtual Slide List

Resources

Access to the supplemental resources for this session is password-protected and restricted to University of Michigan students. If you are a University of Michigan student enrolled in a histology course at the University of Michigan, please click on the following link and use your Kerberos-password for access to download lecture handouts and the other resources.

Resources on M+Box

This collection was originally compiled by Kent Christensen, Ph.D., J. Matthew Velkey, Ph.D., Lloyd M. Stoolman, M.D., Laura Hessler, and Diedra Mosley-Brower. Currently, it is curated by Michael Hortsch, Ph.D. If you have questions or comments regarding the University of Michigan virtual slide collection, please contact Dr. Hortsch at hortsch at umich.edu.

Virtual Slide List for Histology Course

Search Description
Cardiovascular System
120
Atrioventricular Valve: Note that the valve is composed of two apposing layers of endocardium. The core of the valve contains loose connective tissue near the surface of the atrioventricular orifice and a thick, dense connective tissue plate on the opposite side. Note the absence of smooth muscle cells or capillaries within the substance of the valve. PATHOLOGY: The small dense spherules in the connective tissue represent the beginning of a calcification process - an aging phenomenon.
339
Chorda Tendinae: In this electron micrograph, study the arrangement of collagenous and elastic fibers in this small tendon. The endocardium is reduced to the layer of endothelial cells.
Cartilage, Bone and Bone Development
020
Trachea, H&E, 40X
040
Trachea, H&E, 40X (hyaline cartilage).
40n
Hyaline cartilage, 1.5um section, H&E, 40X
044
Ear pinna, aldehyde fuchsin and Masson, 20X (elastic cartilage).
044H
Epiglottis, H&E, 20X (elastic cartilage).
045
Intervertebral disc, H&E, 40X (fibrocartilage and dense irregular connective tissue, nucleus pulposus).
046HF
Fetal face, frontal section, H&E, 40X (intramembranous bone formation in maxilla, osteocyte, osteoblast, osteoclast).
046M
Fetal face, frontal section, 40X (intramembranous bone formation in maxilla, osteocyte, osteoblast, osteoclast).
46MN
Embryonic face, Masson trichrome stain, 40X
47
Knee, sheep embryo, H&E, 20X
048
Fetal leg, cross section, H&E, 40X (spongy bone, osteoblasts, osteoclasts, appositional bone growth on surface of long bone).
048b
Fetal leg, cross section, Masson stain, 40X (spongy bone, appositional bone growth on surface of long bone).
049
Developing long bone (humerus), H&E, 20X (epiphyseal plate, zones of proliferation, hypertrophy, calcification and ossification).
049
Humerus, H&E, 40X
050
Decalcified bone, cross section, H&E, 40X (compact bone, osteons = Haversian systems).
051
Ground section of compact bone, longitudinal, 20X (osteons = Haversian systems, lacunae for osteocytes, canaliculus, Volkmann's = nutrient canals).
051L-EX
Ground section of compact bone, longitudinal section, 40X (osteons = Haversian systems, lacunae for osteocytes, canaliculus, Volkmann's = nutrient canals).
093A
Ground section of compact bone, cross section, 40X (thinner - good for viewing lacunae and canaliculi).
093B
Ground section of compact bone, cross section, 40X (osteons = Haversian systems, lacunae for osteocytes, canaliculus, Volkmann's = nutrient canals).
093C
Ground section of compact bone, longitudinal section, 40X (osteons = Haversian systems, lacunae for osteocytes, canaliculus, Volkmann's = nutrient canals).
108
Finger, H&E, 20X (endochondral bone formation, various zones).
110
Finger, H&E, 20X (endochondral bone formation).
115-M
Palate, saggital section, Masson stain, 40X (intramembranous bone formation, spongy bone, compact bone).
115-N
Palate, saggital section, H&E, 40X (intramembranous bone formation, spongy bone, compact bone).
120
Fetal face and jaw, frontal section, H&E, 40X (intramembranous bone formation in maxilla).
120N
Head, 66mm embryo, H&E, 40X
126
Trachea and esophagus, H&E, 40X (hyaline cartilage, in trachea at upper left).
UCSF 053
 Ear pinna, van Gieson's stain, 40X
UCSF 081
Vertebrae, 7 mo. fetus, trichrome stain, 40X
UCSF 083
Knee joint, 4.5 mo. fetus, trichrome stain, 40X
UCSF 095
Tibia, broken, rat, trichrome stain, 40X
075
Hyaline Cartilage: Note the abundance of intercellular matrix. Study the development of chondrocytes from chondroblasts.
076
Chondrocyte (Hyaline Cartilage): Note that the collagenous fibrils are partially obscured and lack obvious periodicity. Note the many cell organelles, such as ribosomes, in this very active chondrocyte.
078
Chondrocyte (Fibrocartilage): This low power electron micrograph nicely depicts the typical appearance of fibrocartilage as found in the intravertebral disk.
079
Chondrocyte (Fibrocartilage): Extracellular collagenous fibrils are coarser in fibrous cartilage than in hyaline cartilage and do show periodicity. They are made of type I collagen. Observe the varied directions of collagenous bundles. The amorphous matrix surrounding the chondrocyte helps distinguish this cell from that of a fibroblast in dense connective tissue.
082
Chondrocyte Detail (Elastic Cartilage): Find the elastic components in the matrix.
083
Endochondrial Ossification (Zones of Chondrocyte Proliferation and Hypertrophy): Study the transition that occurs in the chondrocytes as they change from very active to hypertrophied and dying.
084
Intramembranous Bone Formation: This is sometimes called "direct" bone formation because it does not involve cartilage. Hence, chrondocytes would not be found in this section. The term "membrane" is used here because the periosteum around forming bone appears like a membrane. Make sure you know the structural and functional differences between an osteoblast and osteocyte. Observe (and remember) that the bone formation, which occurs from the periosteum of the diaphysis of long bones is identical to the process of intramembranous bone formation. In this unique micrograph, study the differentiation of osteoprogenitor cells to osteoblasts and subsequently to osteocytes. Note the formation of long cell processes as the osteoblast (lower right corner) prepares for the transformation into an osteocyte. Find the cell process, which is already located in a canaliculus.
086
Endochondrial Ossification (Zones of Hypertrophy and Calcification): Study the changes that are associated with the removal of the cartilage and the deposition of a bone matrix.
090
Osteocyte: The calcium crystals of the bone matrix were removed in this preparation by a decalcification process. Note how coarse the collagenous fibrils are and the difficulty in visualizing the periodicity of the fibrils (probably due to the process of mineralization).
091
Osteoclast: The osteoclast is a very large cell (multinucleated) that sits on the surface of bone matrix. Note the many lysosomes and phagocytic vacuoles. Most osteoclasts are thought to arise by fusion of monocyte-macrophages.
093
Haversian Canal: Note the "inactive" appearance of endosteal cells. The presence of a macrophage in the Haversian canal indicates the potential eroding function of the endosteal lining of the canal.
Cell Biology
011
Nuclear Envelope: This electron micrograph nicely depicts the double membrane of the nuclear envelope including some nuclear pores.
012
Pancreas - Rough Endoplasmic Reticulum (rER): This electron micrograph shows the typical flat cisternae of the rough endoplasmic reticulum, which are studded with ribosomes.
013
Golgi Apparatus: The Golgi apparatus looks rather unusual in this electron micrograph. This is due to the enlarged stacks of cisternae (Golgi vacuoles), which distort the appearance of the Golgi complex.
014
Centrioles: This image shows two centrioles, which represent the central structure of the microtubule-organizing center (MTOC). Some microtubules are also visible in the vicinity.
016
Desmosome and Intermediate Filaments: A desmosome can be seen in the upper right corner of this transmission electron micrograph. The cytoplasm is full of intermediate filaments (tonofilaments), some of which are attached to the desmosomal plaque.
021
Plasma Cell: This electron micrograph shows a typical secretory cell, a plasma cell, which secretes immunoglobulin protein. Many of the major types of cellular organelles are visible in this image. In the nucleus, areas of euchromatin and heterochromatin can easily be identified.

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