This collection was originally compiled by Kent Christensen, Ph.D., J. Matthew Velkey, Ph.D., Lloyd M. Stoolman, M.D., Laura Hessler, and Diedra Mosley-Brower. Currently, it is curated by Michael Hortsch, Ph.D. If you have questions or comments regarding the University of Michigan virtual slide collection, please contact Dr. Hortsch at hortsch at umich.edu.
Virtual Slide List
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Resources
Access to the supplemental resources for this session is password-protected and restricted to University of Michigan students. If you are a University of Michigan student enrolled in a histology course at the University of Michigan, please click on the following link and use your Kerberos-password for access to download lecture handouts and the other resources.
Virtual Slide List for Histology Course
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155
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Cilia: Cross sections of cilia. The typical 9+2 arrangement of the microtubules is especially evident in EM #156. | |
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156
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Cilia: Cross sections of cilia. The typical 9+2 arrangement of the microtubules is especially evident. The basal bodies are centrioles and have 9 triplets of microtubules with no central pair. | |
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170
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Brush Border: This EM micrograph depicts the typical appearance of microvilli on the apical surface of two types of cells with a striated or brush border. Shown is the epithelial lining cell of a proximal tubule in the kidney. | |
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213
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Microvilli: Study the typical appearance of microvilli on the apical surface of this cell forming part of the striated or brush border in small intestine. | |
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227
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Organelles of the Secretory Pathway: Pancreatic acinar cells as depicted in this electron micrograph are cells that are highly specialized for protein secretion. Therefore, all the organelles of the protein secretory pathway are well-represented and are clearly visible in this micrograph. |
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65-1
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Spinal cord and dorsal root ganglion, H&E, 20X (white matter [pinkish], gray matter [grayish], dorsal horn, ventral horn, ventral horn cells [large motor neuron cell bodies], neuropil,dorsal root ganglion [at right], sensory neurons,capsular cells, sensory axon tracts). | |
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65-1N
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Spinal cord, trichrome stain, 40X | |
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65-2
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Spinal cord and dorsal root ganglion, H&E, 40X (see above for structures, the section is upside down [dorsal is downward] and much of it is out of focus, there are dorsal root ganglia at both right and left). | |
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66a
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Thoracic spinal cord, cross section, luxol blue staining, 40X | |
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76
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Cerebrum, axons and neuron cell bodies stained blue, 40X (white matter [stained dark blue], cerebral cortex, pyramidal cells, pyramid shaped neuron cell bodies of various size, dendritic tree not visible, axon goes to white matter], glial cells, sulcus [white line from top to bottom of this section] between gyri. | |
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76b
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Cerebrum, TB&E stain, 40X | |
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77
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Cerebellum, H&E, 20X (white matter [pink, lower center and upward], gray matter [molecular layer, Purkinje cells, granular layer]). | |
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77
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Cerebellum, H&E, 40X (detail of previous slide, molecular layer [small axons give input to Purkinje dentrites], Purkinje cell bodies [very large, extensive dendritic trees not visible, axons go through granular layer to white matter], granular layer [dark layer, granule cells]. | |
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77a
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Cerebellum, luxol blue stain, 40X | |
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13270
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Astrocytes, Gold-staining | |
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NP004N
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Hippocampal region, coronal section, luxol blue stain, 40X | |
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048
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White Matter (Spinal Cord): In this field you see several oligodendrocytes, the cells that make myelin in the CNS, surrounded by numerous myelinated axons of various size, cut in cross section. | |
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049
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Motor Neuron Cell Body: In this electron micrograph, note some of the features you saw in ventral horn motor neurons with the light microscope, such as the large, pale nucleus, prominent nucleolus, Nissl bodies, dendrites and axon. Adjacent to the neuron, note myelinated axons of various sizes and also that there is no space between cell processes-all space is occupied either by the processes of neurons or glia, or by capillaries (capillaries are somewhat swollen here because the tissue was fixed by perfusion). |
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018
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Loose Connective Tissue: In this micrograph of loose connective tissue of the tracheal mucosa numerous (labeled) cells of the connective tissue are present. Note the relative size of the different cell types, their shapes, amount of rough ER and variously sized granules and inclusions. Then use your text and atlas to review the diagnostic features of each connective tissue cell present in the micrograph. Note the paucity of collagen fibrils. | |
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020
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Mast Cell: Mast cells contain a mixture of granule types reflective of the variety of substances they secrete. Histamine and heparin are found in the more "regular" looking granules (evenly dark and round). Other secretory products include leukotrienes and other phospholipid derivatives, which are made from the sheets of membranes arranged as lamella, whorls, or even scroll-like bodies within the more irregular appearing granules. | |
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021
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Plasma Cel: A plasma cell is a typical secretory cell, which secretes immunoglobulin protein. Many of the major types of cellular organelles engaged in secreting protein via the secretory pathway are visible in this image. Especially, note the abundance of RER. In the nucleus, areas of euchromatin and heterochromatin can easily be identified. | |
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023
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Fat Cells: This electron micrograph depicts mature fat cells. You can see one large lipid droplet in the cytoplasm of each cell. The nuclei of many cells are not included in the field of view. Brown fat cells would have several small lipid droplets all of which would be roughly the same size. Remember that each fat cell is enclosed by a thin basal lamina (Unfortunately, in these examples you can’t see the basal lamina). | |
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025
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Fibroblast: Observe the large amount of rough endoplasmic reticulum (ER) in these cells. Is this an indication of an active or inactive cell? | |
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026
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Dense Connective Tissue: Note the alternating layers of fibroblasts and collagenous fiber bundles. Make sure you can see the difference between cross sectioned and longitudinally sectioned collagenous fibrils. | |
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027
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Elastic Connective Tissue: Observe the branching nature of the elastic fiber and the "mantle" of elastic microfibrils. The cross banding of the collagenous fibrils is easily observed. | |
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028
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Collagen and Elastin: Observe the mixture of collagen and elastic fibers in this cross section of chorda tendinea. Although collagen fibers mostly fill the view, there are numerous elastic fibers, which provide the elasticity essential for the function of the tissue. | |
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029
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Regular Dense Connective Tissue: Note the uniform distribution of regularly arranged collagen fibers (type I). | |
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063
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Macrophage: Tissue macrophages can be found in many different organs. As they have a phagocytic function, removing pathogens and cell debris, macrophages usually contain abundant primary and secondary lysosomes. |
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114R
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Lip, H&E, 40X (oral mucosa, vermillion border, thin skin, skeletal muscle, small salivary glands, hair follicles, sebaceous glands). CURRENTLY NOT AVAILABLE | |
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114M
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Lip, H&E, 20X (oral mucosa, vermillion border, thin skin, skeletal muscle, small salivary glands, hair follicles, sebaceous glands). | |
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114 triC
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Fetal palate, trichrome stain, 40X | |
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115
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Palate, H&E, 20X (lip, developing tooth, hard palate, soft palate, oral mucosa [keratinized, non keratinized], respiratory mucosa). | |
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115
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Palate, Masson trichrome stain, 40X (lip, developing tooth, hard palate, soft palate, oral mucosa [keratinized, non keratinized], respiratory mucosa). | |
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116
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Tongue, H&E, 20X (filiform papillae, fungiform papillae, skeletal muscle). | |
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117
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Tongue, H&E, 20X (circumvalate papilla, trench, taste buds, serous glands [von Ebner], fungiform papillae). | |
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117
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Tongue, H&E, 40X (circumvalate papilla, trench, taste buds, serous glands [von Ebner's glands], fungiform papillae). | |
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117N
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Tongue, rabbit, H&E, 40X (circumvallate papilla) | |
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122
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Tooth and gingiva, Masson trichrome stain, 20X (crown, root, dentin, pulp cavity, cementum, periodontal membrane, alveolar bone, gingiva [=gum]). | |
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122PAS
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Tooth and gingiva, PAS stain, 20X (crown, root, dentin, pulp cavity, cementum, periodontal membrane, alveolar bone [=gum]). | |
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123
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Tooth, pig, H&E, 40X | |
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180-1
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Parotid gland, H&E, 40X (acini, centroacinar cells, fat cells, striated ducts, intercalated ducts, interlobular ducts). | |
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180-2
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Parotid gland, H&E, 40X (acini, centroacinar cells, fat cells, striated ducts, intercalated ducts, interlobular ducts). | |
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183-1
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Submandibular gland, H&E, 40X (serous acini, mucous acini, striated ducts, intercalated ducts). | |
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183-2
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Submandibular gland, mucicarmine stain [stains mucins red], 20X (serous acini, mucous acini, striated ducts, intercalated ducts). CURRENTLY NOT AVAILABLE | |
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184
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Submandibular gland, H&E, 20X (serous acini, mucous acini, striated ducts, intercalated ducts). | |
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184
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Submandibular gland, H&E, 40X (serous acini, mucous acini, striated ducts, intercalated ducts). | |
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185A
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Sublingual gland, mucicarmine stain, 20X (mucous acini, serous acini, striated ducts, intercalated ducts, interlobular ducts). | |
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185-1
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Sublingual gland, H&E, 40X (mucous acini, serous acini, striated ducts, intercalated ducts, interlobular ducts). CURRENTLY NOT AVAILABLE | |
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185-2
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Parotid gland, H&E, 40X | |
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184
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Filiform Papilla (Tongue): Note the abundant deposit of keratin on the surface of the tongue and the characteristic shape of the filiform papilla show in this electron micrograph. Taste buds are NOT associated with filiform papillae. |